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Collaborations and partnerships

While SynGenome contains a large number of total sequences, there may be fewer sequences in the database for your function of interest. If you are interested in conducting a semantic design project beyond the scale of SynGenome, please reach out as we are eager to collaborate. A design project could be a good contender for semantic design if:

1. Your desired function is encoded by prokaryotic or phage genomes. These could include nucleases, protein-based antimicrobials, transposons, polymerases, DNA/RNA binding proteins, or metabolic enzymes.


2. You have a simple low- to medium-throughput experimental pipeline for testing your desired function. While higher throughput is usually better, we have had experimental success rates of 17-50% screening 10-84 designs.

Outcomes from this process may include: (1) the diversification of existing proteins to design new, higher activity variants; (2) identifying the function of a natural protein of unknown function; or (3) the design of functional proteins with low homology to nature.

If you are interested in working together, please fill out this Google form to begin the conversation!

Discussions

The SynGenome website code is open source and available at https://github.com/brianhie/syngenome. If you have feature requests, bug reports, or any other questions/comments, please use our GitHub Discussions page.