Brian Hie

Laboratory of Evolutionary Design

Aligning biological AI with human good at Stanford University


Our mission is to ensure that the AI revolution in biology occurs in a way that benefits humanity.
We aim to design biology that counteracts evolving threats and accomplishes useful new functions.


Some of our research progress is described in the selected publications below.

Sequence modeling and design from molecular to genome scale with Evo
A unifying model of genomic data
Efficient evolution of human antibodies from general protein language models
Making better antiviral antibodies
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Unsupervised evolution of protein and antibody complexes with a structure-informed language model
Making even better antiviral antibodies
Learning the language of viral evolution and escape
Understanding how viruses resist us
Evolutionary velocity with protein language models predicts evolutionary dynamics of diverse proteins
Modeling long-term evolution
View all publications